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1995-03-04
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Document 0219
DOCN M9550219
TI HIV mass screening of infants and mothers: historical, technical, and
practical issues.
DT 9505
AU Grady GF; Theobald Smith Research Institute, State Laboratory
Institute,; Jamaica Plain, MA.
SO Acta Paediatr Suppl. 1994 Aug;400:39-42. Unique Identifier : AIDSLINE
MED/95135017
AB Screening groups of anonymous infants for HIV antibody, as an index of
maternal infection rates, has been a widely used seroepidemiological
method since being introduced in 1986 in Massachusetts (USA). One
shortcoming has been the applicability only to parturient women, thus
necessitating corrections for fertility rates in extrapolation to all
women. A second disadvantage has been controversy and confusion about
the distinction between anonymous seroprevalence studies and linked
testing. However, there have been major advantages such as the leading
indicator nature of the data obtained. Experience with screening nearly
a half million Massachusetts newborns through December 1992 has shown
seroprevalence rates stabilizing at 2.4 per 1000, and with consistent
10-fold differences between groups of birth hospitals serving different
socio-economically defined populations. In addition to predicting the
future of the AIDS epidemic in children, the information provides a
reference point for comparing the completeness of targeted
identifications of HIV infection in mothers and infants.
DE Comparative Study Female Human HIV
Infections/EPIDEMIOLOGY/IMMUNOLOGY/*PREVENTION & CONTROL *HIV
Seroprevalence Infant, Newborn Male *Mass Screening
Massachusetts/EPIDEMIOLOGY *Mothers Neonatal Screening North
Carolina/EPIDEMIOLOGY Pilot Projects Rural Population Socioeconomic
Factors Suburban Population Support, U.S. Gov't, P.H.S. Urban
Population JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).